Permacol™ surgical implant is a porcine dermal collagen implant from which cells, cell debris, DNA and RNA are removed in a gentle process that is not damaging to the 3D collagen matrix. The resulting acellular collagen matrix is then cross-linked for enhanced durability.
The cross-linking of Permacol™ surgical implant offers advantages over many other collagen-based implants for hernia and abdominal wall repair. Human cadaveric grafts and other non-crosslinked grafts may have initial success due to rapid tissue remodeling but may ultimately result in loss of tensile strength, increased tissue laxity and high recurrence rates that require additional surgical revisions.1-8 With its optimal cross-linking and gentle processing methods, Permacol™ surgical implant offers long-lasting dimensional stability that ensures the integrity of the collagen graft lasts through the body's wound healing process.
Requiring no rehydration or refrigeration, Permacol™ surgical implant is ready to use when needed and is dimensionally stable. It is available in a wide variety of sizes, including larger sizes that eliminate the need for suturing multiple pieces together and provide the right size of implant regardless of the size of the defect.
Features and Benefits
| Features | Benefits |
|---|---|
| Biocompatible Acellular Porcine Dermal Collagen | Similar to human collagen structure. Supports ingrowth and neovascularization. |
| Patented Cross-Linking with HMDI | Slows the breakdown of the collagen scaffold by collagenase, providing durability in soft tissue repairs. |
| Multiple sizes, Including Large Sizes | A wide range of sizes to match specific clinical needs. No need for suturing multiple pieces together for large repairs. |
| Prehydrated | Comes ready to use requiring no rehydration in the OR, improving OR efficiency. |
| No Refrigeration Required | No special storage requirements in the hospital. |
| Burst and Tear Strength Comparable to Synthetics | Confidence in strength of the repair. |
| Terminally Sterilized using Gamma Irradiation | Safe implant removing risk for disease transmission. |
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Gaertner, W.G., et al. Experimental Evaluation of Four Biologic Prostheses for Ventral Hernia Repair. J. Gastrointest Surg. 2007
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Zheng, F, et al. Host Response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model. American Journal of Obstetrics and Gynecology(2004)191,1961-70
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Novi, J.M., et al. Vaginal Paravaginal Repair using Human Cadaveric versus Porcine Dermal Implant: A Survival Analysis. Ohio Research and Clinical Review Fall 2006.
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Jin, J, et al. Abdominal Hernia Repair with Bridging Acellular Dermal Matrix - An Expensive Hernia Sac. American Hernia Society March 2007.
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Jin, J, et al. Use of Acellular Dermal Matrix for Complicated Ventral Hernia Repair: Does Technique Affect Outcomes? Journal of the American College of Surgeons Volume 205, Issue 5, November 2007, Pages 654-660.
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Rodriguez, Eduardo, et al. Abdominal Wall Reconstruction following Severe Loss of Domain: The R Adams Cowley Shock Trauma Center Algorithm. PRSJournal September 2007 DIO:10.1097/01/prs0000270303.44219.76.
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Newcomb, W.; Heniford, T, et al . Long-term Outcomes After Abdominal Wall Reconstruction With Acellular Human Dermis in Patients With Abdominal Injuries. 2007 AAST Session IV, Poster #10
Frequently Asked Questions
| Question | Answer |
|---|---|
| I have tried porcine and/or other natural tissues. How is Permacol Surgical Implant different? | Permacol™ surgical implant is derived from pig dermis and rendered acellular and inert via organic and enzymatic extraction processes. The tissue is then crosslinked with non-calcifying HMDI to make it durable and highly resistant to breakdown by naturally occurring collagenases. |
| Has Permacol™ Surgical Implant been widely used? | Permacol™ surgical implant has been used in over 250,000 procedures worldwide. This material has been used successfully for tissue repair across many surgical disciplines, including general surgery, plastic, colorectal, orthopedic, urological and gynecological procedures. |
| Are there special instructions for implanting or anchoring the tissue? | No change in surgical technique is needed with Permacol™ surgical implant. It can be anchored according to surgeon preference, using either suture material or fixation. If suturing is preferred, Covidien recommends a long-lasting resorbable or permanent suture as well as the use of tapered needles. The tissue can be cut, shaped or layered to meet the anatomical need. Both sides of the implant are the same and no special positioning or orientation is required. |
| Does Permacol™ Surgical Implant eventually resorb? What happens to the tissue over time? | Crosslinking with HMDI results in an implant that resists breakdown by collagenase and maintains its structural integrity after implantation. The implant acts as a scaffold for rapid cellularization and ingrowth into host tissue. |
| How is the product packaged? | Permacol™ surgical implant is packaged hydrated and ready to use in a sterile inner foil pouch, then sealed in a clear, non-permeable outer pouch. The sterile inner pouch is ready to be placed onto a sterile field. Once opened, the implant should be placed in a basin of sterile saline until ready to be implanted; it should not be allowed to dry out, since it cannot be rehydrated. |
Not available in all markets.
Covidien products should only be used by responsible and experienced surgical practitioners.
